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The killer-cell immunoglobulin-like receptors (KIRs), which bind MHC class I molecules, represent an important family of natural killer (NK) cell receptors. Combinations of MHC class I and KIR influence resistance to infections, susceptibility to autoimmune diseases and complications of pregnancy, as well as outcome of allogeneic stem cell transplantation. Such correlations suggest that KIR molecules are important immunogenetic factors in human disease and clinical medicine. The 2011 KIR workshop will cover the following topics: KIR evolution, population genetics, functional aspects of KIR, KIR in health and disease: cancer, reproduction and infection.

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Organized by:

Karl-Johan Malmberg M.D., Ph.D., Hans-Gustaf Ljunggren M.D., Ph.D. and
Jakob Michaëlsson Ph.D.

Center for Infectious Medicine (CIM) and
Immunomodulatory Therapies against Autoimmunity and Cancer (IMTAC)

Karolinska Institutet and Karolinska University Hospital